Low Testosterone Levels in Body Fluids Are Associated With Chronic Periodontitis

Research has found significant connections between periodontitis and systemic health issues like heart disease, diabetes, and even Alzheimer’s disease. But while studies of periodontitis and levels of testosterone have suggested a relationship, they have been less conclusive. An international team of researchers recently reviewed 8 studies that investigated testosterone and chronic periodontitis.

Sergio V. Kellesarian of the department of general dentistry at the Eastman Institute for Oral Health, University of Rochester, shared his insights from that work. In the past 30 years, bidirectional linkages between chronic periodontitis and several systemic conditions such as atherosclerosis, myocardial infarction, and diabetes mellitus have been reported extensively. Likewise, the relationship between female sex hormones (estrogens) and periodontal disease in women during puberty, pregnancy, and menopause or in women taking oral contraceptives has been widely reported.

However, the relationship between chronic periodontitis and men’s reproductive health has been overlooked and scarcely reported. Therefore, we conducted searches using indexed databases to assess the link between periodontal diseases and men’s reproductive health conditions, such as erectile dysfunction, male infertility, and low testosterone levels. several factors may have biased the results of the included studies accounting for the range of results. For example, different factors might influence testosterone levels, including aging, genetics, and comorbidities such as glycemic levels and obesity. Among the included studies we noticed that the participants’ ages varied significantly. One study analyzed testosterone levels in men between 19 and 21 years old. Another study assessed testosterone levels in patients aged between 66 and 95 years old. Moreover, it is pertinent to mention that around 50% of the studies included did not adjust the results for confounder’s factors, such as smoking and obesity. Therefore, we recommend additional prospective studies including stringent confounder assessment, larger samples, longer periods of time, and different ethnicities.

Full research here.